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Biosci Biotechnol Biochem. 2006 Feb;70(2):546-50.

Transcriptome analysis reveals global expression changes in an industrial L-lysine producer of Corynebacterium glutamicum.

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  • 1Biofrontier Laboratories, Kyowa Hakko Kogyo Co., Ltd., Tokyo, Japan.


Toward the elucidation of advanced mechanisms of L-lysine production by Corynebacterium glutamicum, a highly developed industrial strain B-6 was analyzed from the viewpoint of gene expression. Northern blot analysis showed that the lysC gene encoding aspartokinase, the key enzyme of L-lysine biosynthesis, was up-regulated by several folds in strain B-6, while no repression mechanism exists in L-lysine biosynthesis of this bacterium. To analyze the underlying mechanisms of the up-regulation, we compared the transcriptome between strain B-6 and its parental wild-type, finding that not only lysC but also many other amino acid-biosynthetic genes were up-regulated in the producer. These results suggest that a certain global regulatory mechanism is involved in the industrial levels of L-lysine production.

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