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Age Ageing. 2006 Mar;35(2):200-1.

Metformin-related vitamin B12 deficiency.

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  • 1Medical and Geriatric Unit, Shatin Hospital, New Territories, Hong Kong, China.


Metformin is an invaluable hypoglycaemic agent. We report two cases who had symptomatic vitamin B12 deficiency related to metformin use; the mechanisms are discussed. The clinician must be aware of the possibility of metformin-associated B12 deficiency in users who suffer cognitive impairment, peripheral neuropathy, subacute combined degeneration of the cord or anaemia.

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