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FEBS Lett. 2006 Mar 6;580(6):1616-20. Epub 2006 Feb 17.

A GABA(A) receptor of defined subunit composition and positioning: concatenation of five subunits.

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  • 1Department of Pharmacology, University of Bern, Friedb├╝hlstrasse 49, CH-3010 Bern, Switzerland.


We show that the five subunits of a gamma-aminobutyric acid type A receptor (GABA(A) receptor) can be concatenated to yield a functional receptor. This concatenated receptor alpha(1)-beta(2)-alpha(1)-gamma(2)-beta(2) has the advantage of a known subunit arrangement. Most of its functional properties are not significantly different from a receptor formed by individual subunits. Extent of expression amounted to about 40% of that of non-concatenated receptors in Xenopus oocytes, after injection of oocytes with comparable amounts of cRNA coding for concatenated and non-concatenated receptors. The ability to express receptors consisting of five subunits enables detailed studies of GABA(A) receptor subtype selective compounds.

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