-
Hydroxyl radical scavenging reactivity of proton pump inhibitors.
ALTANA Pharma AG, Byk Guldenstrasse 2, D 78464 Konstanz, Germany. simon@altanapharma.com
In addition to the established control of acid secretion of the class of proton pump inhibitors (PPI) reactivity from the pyridyl methyl sulphinyl benzimidazole type a second independent anti-inflammatory reactivity was observed in vitro. This inhibitory reactivity was clearly noticed using three different assays where the aggressive hydroxyl radicals were successfully trapped in a concentration dependent manner. There is unequivocal evidence that the proton pump inhibitors having the sulphoxide group are able to scavenge hydroxyl radicals which are generated during a Fenton reaction. By way of contrast, the corresponding thioethers were substantially less active. No detectable effect was seen in the superoxide radical scavenging system. In conclusion, pantoprazole as well as the other proton pump inhibitors have a pronounced inhibitory reactivity towards hydroxyl radicals.
PMID: 16494850 [PubMed - indexed for MEDLINE]
-
Patient Drug Information
-
Esomeprazole (Nexium® )
Esomeprazole is used to treat gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and injury of the esophagus (food pipe between the mouth and stomach) in ...
-
Omeprazole (Prilosec® , Prilosec® OTC, Zegerid® )
Prescription omeprazole is used alone or with other medications to treat ulcers (sores in the lining of the stomach or small intestine); gastroesophageal reflux disease (GERD), a condition in which backward flow of acid ...
-
Dexlansoprazole (Kapidex® )
Dexlansoprazole is used to treat heartburn in people who have gastroesophageal reflux disease (GERD; condition in which backward flow of acid from the stomach causes symptoms such as heartburn, burping, and sour taste). ...
- »
See all 5 drug reports
...