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Nat Rev Mol Cell Biol. 2006 Jan;7(1):54-62.

Function and regulation of Rnd proteins.

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  • 1Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, 660 Route des Lucioles, Sophia Antipolis, 06560 Valbonne, France. chardin@ipmc.cnrs.fr


The Rnd proteins, which form a distinct sub-group of the Rho family of small GTP-binding proteins, have been shown to regulate the organization of the actin cytoskeleton in several tissues. In the brain, they participate in neurite extension, whereas in smooth muscle, they modulate contractility. Recent evidence has shown that Rnd3 (RhoE) is also involved in the regulation of cell-cycle progression and transformation, indicating that these proteins might have other, as yet unexplored roles.

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