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Chem Biol. 2006 Feb;13(2):115-6.

Targeting HSP90 to halt neurodegeneration.

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  • 1Department of Physiology, Michigan State University, East Lansing, 48824, USA.

Abstract

Activation of c-jun N-terminal kinase (JNK) signaling is associated with neuronal cell death. As described in this issue of Chemistry & Biology, cell-based screening efforts yielded a compound, AEG3482, which interacts with heat shock protein 90 leading to inhibition of JNK and blockade of neuronal apoptosis .

PMID:
16492558
[PubMed - indexed for MEDLINE]
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