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1: Chem Biol Drug Des. 2006 Jan;67(1):85-6.Click here to read Links

A chemogenomic approach to discovering target-selective drugs.

Janzen WP, Hodge CN.

Amphora Discovery Corporation, 800 Capitola Drive, Durham, NC 27713, USA.

An approach is described for identifying scaffolds with predefined selectivity profiles directly from a high-quality high-throughput screening data set, and monitoring that selectivity profile throughout the drug discovery process. This approach results in reduced drug development timelines from "hit" to "lead" stage, and should reduce liabilities for a molecule advancing through the development process.

PMID: 16492154 [PubMed - indexed for MEDLINE]