Virchows Arch. 2006 Apr;448(4):517-20. Epub 2006 Feb 18.

alpha-fetoprotein expression in a dedifferentiated liposarcoma.

Bosco M, Allia E, Coindre JM, Odasso C, Pagani A, Pacchioni D.

Source

Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy.

Abstract

Extremely rare cases of paraneoplastic syndromes or ectopic production of proteins associated with liposarcoma are reported in literature. We describe a unique case of relapsing retroperitoneal dedifferentiated liposarcoma with biochemical, immunohistochemical, and molecular evidence of alpha-fetoprotein (AFP) ectopic production. The lesion was associated to elevated AFP plasma levels that subsided after tumor removal. Immunohistochemical studies showed AFP production by a minority of tumor cells and reverse transcriptase polymerase chain reaction confirmed AFP mRNA expression. Finding of MDM2 and CDK4 iperexpression by immunohistochemistry confirmed the diagnosis of dedifferentiated liposarcoma.

PMID:: 16489442; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Supplemental Content

Related citations

Overlapping features between dedifferentiated liposarcoma and undifferentiated high-grade pleomorphic sarcoma. [Am J Surg Pathol. 2009]
Overlapping features between dedifferentiated liposarcoma and undifferentiated high-grade pleomorphic sarcoma.
Chung L, Lau SK, Jiang Z, Loera S, Bedel V, Ji J, Weiss LM, Chu PG. Am J Surg Pathol. 2009 Nov; 33(11):1594-600.
Dedifferentiated liposarcoma with rhabdomyoblastic differentiation. [Virchows Arch. 2005]
Dedifferentiated liposarcoma with rhabdomyoblastic differentiation.
Shimada S, Ishizawa T, Ishizawa K, Kamada K, Hirose T. Virchows Arch. 2005 Nov; 447(5):835-41. Epub 2005 Jul 13.
Dedifferentiated liposarcomas with divergent myosarcomatous differentiation developed in the internal trunk: a study of 27 cases and comparison to conventional dedifferentiated liposarcomas and leiomyosarcomas. [Am J Surg Pathol. 2007]
Dedifferentiated liposarcomas with divergent myosarcomatous differentiation developed in the internal trunk: a study of 27 cases and comparison to conventional dedifferentiated liposarcomas and leiomyosarcomas.
Binh MB, Guillou L, Hostein I, Château MC, Collin F, Aurias A, Binh BN, Stoeckle E, Coindre JM. Am J Surg Pathol. 2007 Oct; 31(10):1557-66.
Review MDM2+/CDK4+/p53+ oral liposarcoma: case report and review of the literature. [Oral Surg Oral Med Oral Pathol Oral Radiol ...]
Review MDM2+/CDK4+/p53+ oral liposarcoma: case report and review of the literature.
Nikitakis NG, Lopes MA, Pazoki AE, Ord RA, Sauk JJ. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Aug; 92(2):194-201.
Review [Identification of genes over-expressed in myxoid/round cell liposarcoma. DNA microarray analysis and immunohistochemical correlation]. [Pathologe. 2010]
Review [Identification of genes over-expressed in myxoid/round cell liposarcoma. DNA microarray analysis and immunohistochemical correlation].
Lanckohr C, Kasprzynski A, Klein-Hitpass L, Homann HH, Lehnhardt M, Müller O, Kuhnen C, Herter P. Pathologe. 2010 Feb; 31(1):60-6.

See reviews... See all...

Cited by 1 PubMed Central article

Retroperitoneal liposarcoma associated with small plaque parapsoriasis. [World J Surg Oncol. 2007]
Retroperitoneal liposarcoma associated with small plaque parapsoriasis.
Tartaglia F, Blasi S, Sgueglia M, Polichetti P, Tromba L, Berni A. World J Surg Oncol. 2007 Jul 9; 5:76. Epub 2007 Jul 9.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

alpha-fetoprotein expression in a dedifferentiated liposarcoma.
alpha-fetoprotein expression in a dedifferentiated liposarcoma.
Virchows Arch. 2006 Apr ;448(4):517-20. Epub 2006 Feb 18 .

PubMed
Altitude and coagulation activation: does going high provoke thrombosis?
Altitude and coagulation activation: does going high provoke thrombosis?
Acta Haematol. 2008 ;119(3):156-7. Epub 2008 Apr 24 .

PubMed
Porphyria cutanea tarda. Don't forget to look at the urine.
Porphyria cutanea tarda. Don't forget to look at the urine.
Postgrad Med. 1999 Apr ;105(4):208-10, 213-4.

PubMed
Medical evaluation and treatment of urolithiasis.
Medical evaluation and treatment of urolithiasis.
Pediatr Clin North Am. 2006 Jun ;53(3):479-91, vii.

PubMed
Groin and abdominal strain injuries in the National Hockey League.
Groin and abdominal strain injuries in the National Hockey League.
Clin J Sport Med. 1999 Jul ;9(3):151-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

alpha-fetoprotein expression in a dedifferentiated liposarcoma.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Supplemental Content

Related citations

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information