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    Nat Cell Biol. 2006 Mar;8(3):238-48. Epub 2006 Feb 19.

    GM130 and GRASP65-dependent lateral cisternal fusion allows uniform Golgi-enzyme distribution.

    Puthenveedu MA, Bachert C, Puri S, Lanni F, Linstedt AD.

    Source

    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

    Abstract

    The mammalian Golgi apparatus exists as stacks of cisternae that are laterally linked to form a continuous membrane ribbon, but neither the molecular requirements for, nor the purpose of, Golgi ribbon formation are known. Here, we demonstrate that ribbon formation is mediated by specific membrane-fusion events that occur during Golgi assembly, and require the Golgi proteins GM130 and GRASP65. Furthermore, these GM130 and GRASP65-dependent lateral cisternal-fusion reactions are necessary to achieve uniform distribution of enzymes in the Golgi ribbon. The membrane continuity created by ribbon formation facilitates optimal processing conditions in the biosynthetic pathway.

    PMID:
    16489344
    [PubMed - indexed for MEDLINE]

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