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Nat Methods. 2006 Mar;3(3):175-7.

Minimotif Miner: a tool for investigating protein function.

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  • 1Department of Computer Science and Engineering, University of Connecticut, Storrs, Connecticut 06269, USA.


In addition to large domains, many short motifs mediate functional post-translational modification of proteins as well as protein-protein interactions and protein trafficking functions. We have constructed a motif database comprising 312 unique motifs and a web-based tool for identifying motifs in proteins. Functional motifs predicted by MnM can be ranked by several approaches, and we validated these scores by analyzing thousands of confirmed examples and by confirming prediction of previously unidentified 14-3-3 motifs in EFF-1.

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