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Trends Biotechnol. 2006 Apr;24(4):163-71. Epub 2006 Feb 20.

Non-enzymatic regeneration of nicotinamide and flavin cofactors for monooxygenase catalysis.

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  • 1Degussa Care & Surface Specialties, Goldschmidt AG, Goldschmidtstrasse 100, 45127 Essen, Germany.


Biocatalytic oxygenation chemistry is a rapidly evolving field in which monooxygenases are the tools of choice. Monooxygenases catalyze many industrially important synthetic transformations; however, their use in preparative applications is hampered by their intrinsic requirement for reducing equivalents. As a result, non-enzymatic strategies--where the reducing equivalents are introduced directly into the catalytic cycle--are being developed to supersede the well-established enzymatic NAD(P)H regeneration systems currently in use. In this review we summarize and evaluate recent achievements in this area.

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