Transplant Proc. 1991 Jun;23(3 Suppl 3):60-3.

Human cytomegalovirus glycoprotein-receptor interactions.

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Division of Infectious Diseases, Stanford University School of Medicine, California.

Abstract

The HCMV envelope glycoprotein having a molecular weight of 86 kd, gH, has been shown to react with a 92 kd protein that can be extracted from HEL fibroblasts. This HCMV-gp86 membrane receptor appears to be present on the surface of both HCMV-permissive and HCMV-non-permissive cells, suggesting that there are factors in addition to viral attachment governing the intracellular replicative process. Another HCMV envelope glycoprotein (gp130/55; gB homologue) binds predominantly to a 31 kd protein with minor bands at 180, 96, and 90 kd. HCMV-gp86 does not bind to the principal gp130/55 receptor.

PMID:: 1648838; [PubMed - indexed for MEDLINE]

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AI05629/AI/NIAID NIH HHS/United States

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