Send to:

Choose Destination
See comment in PubMed Commons below
Trends Parasitol. 2006 Apr;22(4):154-9. Epub 2006 Feb 20.

Do trematode parasites disrupt defence-cell signalling in their snail hosts?

Author information

  • 1School of Life Sciences, Kingston University, Penrhyn Road, Kingston-upon-Thames, Surrey, UK, KT1 2EE.


More than a decade ago, it was postulated that components derived from trematode parasites block receptors on the defence cells of their snail intermediate hosts, thus preventing host-cell activation and parasite elimination. This phenomenon has still not been investigated extensively. However, recent work concerning the molecular regulation of the molluscan defence response provides a new framework for studies that focus on an extension of this original concept - subversion of host cell signalling by trematode parasites. The hypothesis is that, to facilitate survival and replication in their intermediate hosts, trematode parasites down regulate host defence responses by interfering with key signal-transduction pathways in snail defence cells.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk