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Parkinsonism Relat Disord. 2006 May;12(4):228-38. Epub 2006 Feb 20.

Enhanced sensitivity of dopaminergic neurons to rotenone-induced toxicity with aging.

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  • 1Department of Medical Pharmacology, Institute for Clinical and Experimental Neurosciences, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands.

Abstract

Rotenone has been reported to induce various degrees of Parkinsonism in rats. We tested whether advancing age alters the sensitivity of dopaminergic neurons to rotenone. A low, systemic dose of rotenone had no effect on young rats, but led to a 20-30% reduction of tyrosine hydroxylase-positive neurons in the substantia nigra of older rats. The effect was specific to nigral dopaminergic neurons and may be associated with the increase of glial cell activation in older rats. These data suggest that age enhances the sensitivity of dopaminergic neurons to rotenone and should be considered when assessing models of Parkinson's disease.

PMID:
16488175
[PubMed - indexed for MEDLINE]
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