Bioorg Med Chem Lett. 2006 May 15;16(10):2796-9. Epub 2006 Feb 17.

Discovery of novel hydroxy pyrazole based factor IXa inhibitor.

Vijaykumar D, Sprengeler PA, Shaghafi M, Spencer JR, Katz BA, Yu C, Rai R, Young WB, Schultz B, Janc J.

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Celera, 180 Kimball Way, South San Francisco, CA 94080, USA. dvijayku@hotmail.com

Abstract

Synthesis and biological data of a novel selective and efficacious factor IXa inhibitor are described along with its crystal structure in factor VIIa.

PMID:: 16487703; [PubMed - indexed for MEDLINE]

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Structures reported by this article

Discovery Of A Novel Hydroxy Pyrazole Based Factor Ixa Inhibitor

PDB: 2FLB

Source: Homo sapiens

Method: X-Ray Diffraction

Resolution: 1.95 Å

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