J Drugs Dermatol. 2006 Feb;5(2 Suppl):17-25.

Current treatments of actinic keratosis.

Source

Gold Skin Care Center, Nashville, TN 37215, USA. drgold@goldskincare.com

Abstract

Actinic keratosis (AK) lesions should be treated because they may evolve into lesions clinically indistinguishable from those of invasive squamous cell carcinoma which require expensive therapy. Treatment options for AK include cryosurgery, curettage and excisional surgery, dermabrasion, chemical peels, laser resurfacing, 5-fluorouracil (5-FU), imiquimod, diclofenac, and tretinoin, each with advantages and limitations. Clinical trial results show that photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) is an effective and safe treatment of nonhypertrophic AK lesions of the scalp and face. ALA-induced protoporphyrin IX may be activated by a variety of light sources. ALA incubation times of 1-hour make ALA PDT a practical procedure for the treatment of AK lesions. Clinical trials show that PDT with methyl aminolevulinate (MAOP) is also a safe and effective treatment of AKs of the face and scalp; MAOP is available in Europe but not in the US at the time of this writing. ALA PDT offers efficacy against multiple AKs without the adverse effects of 5-FU or imiquimod.

PMID:: 16485877; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Supplemental Content

Save items

Related citations in PubMed

Photodynamic therapy using aminolaevulinic acid for patients with nonhyperkeratotic actinic keratoses of the face and scalp: phase IV multicentre clinical trial with 12-month follow up. [Br J Dermatol. 2006]
Photodynamic therapy using aminolaevulinic acid for patients with nonhyperkeratotic actinic keratoses of the face and scalp: phase IV multicentre clinical trial with 12-month follow up.
Tschen EH, Wong DS, Pariser DM, Dunlap FE, Houlihan A, Ferdon MB, Phase IV ALA-PDT Actinic Keratosis Study Group. Br J Dermatol. 2006 Dec; 155(6):1262-9.
Short incubation PDT versus 5-FU in treating actinic keratoses. [J Drugs Dermatol. 2003]
Short incubation PDT versus 5-FU in treating actinic keratoses.
Smith S, Piacquadio D, Morhenn V, Atkin D, Fitzpatrick R. J Drugs Dermatol. 2003 Dec; 2(6):629-35.
ALA/PDT in the treatment of actinic keratosis: spot versus confluent therapy. [J Cosmet Laser Ther. 2003]
ALA/PDT in the treatment of actinic keratosis: spot versus confluent therapy.
Goldman M, Atkin D. J Cosmet Laser Ther. 2003 Jun; 5(2):107-10.
The use of photodynamic therapy in dermatology: results of a consensus conference. [J Drugs Dermatol. 2006]
The use of photodynamic therapy in dermatology: results of a consensus conference.
Nestor MS, Gold MH, Kauvar AN, Taub AF, Geronemus RG, Ritvo EC, Goldman MP, Gilbert DJ, Richey DF, Alster TS, et al. J Drugs Dermatol. 2006 Feb; 5(2):140-54.
Review Levulan: the first approved topical photosensitizer for the treatment of actinic keratosis. [J Dermatolog Treat. 2002]
Review Levulan: the first approved topical photosensitizer for the treatment of actinic keratosis.
Jeffes EW. J Dermatolog Treat. 2002; 13 Suppl 1:S19-23.

See reviews... See all...

Cited by 2 PubMed Central articles

Considerations for use of Fluorouracil cream 0.5% for the treatment of actinic keratosis in elderly patients. [J Clin Aesthet Dermatol. 2008]
Considerations for use of Fluorouracil cream 0.5% for the treatment of actinic keratosis in elderly patients.
Werschler WP. J Clin Aesthet Dermatol. 2008 Jul; 1(2):22-7.
The impact of the current United States guidelines on the management of actinic keratosis: is it time for an update? [J Clin Aesthet Dermatol. 2010]
The impact of the current United States guidelines on the management of actinic keratosis: is it time for an update?
Martin G. J Clin Aesthet Dermatol. 2010 Nov; 3(11):20-5.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Current treatments of actinic keratosis.
Current treatments of actinic keratosis.
J Drugs Dermatol. 2006 Feb ;5(2 Suppl):17-25.

PubMed
Two apolipoprotein E5 variants illustrate the importance of the position of addi...
Two apolipoprotein E5 variants illustrate the importance of the position of additional positive charge on receptor-binding activity.
J Lipid Res. 1991 Mar ;32(3):521-8.

PubMed
Combat and warfare in the early paleolithic and medically unexplained musculo-fa...
Combat and warfare in the early paleolithic and medically unexplained musculo-facial pain in 21st century war veterans and active-duty military personnel.
Hawaii Dent J. 2005 Nov-Dec ;36(6):16-8.

PubMed
Conjugative transposition of Tn916 requires the excisive and integrative activit...
Conjugative transposition of Tn916 requires the excisive and integrative activities of the transposon-encoded integrase.
J Bacteriol. 1991 Jul ;173(14):4347-52.

PubMed
[Rationale, characteristics and study design of PREAMI (Perindopril and Remodell...
[Rationale, characteristics and study design of PREAMI (Perindopril and Remodelling in the Elderly with Acute Myocardial Infraction)].
Ital Heart J. 2005 Nov ;6 Suppl 7:14S-23S.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Current treatments of actinic keratosis.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Other Literature Sources

Education

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information