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Crit Care Med. 2006 Apr;34(4):1080-6.

Statin use and mortality within 180 days after bacteremia: a population-based cohort study.

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  • 1Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark.

Abstract

OBJECTIVE:

To examine the association between preadmission statin use and mortality among patients with bacteremia in a population-based setting.

DESIGN:

Observational study based on prospective registration of bacteremia episodes and mortality over a 6-yr period.

SETTING:

North Jutland County, Denmark (population, 500,000).

PATIENTS:

A total of 5,353 adult patients hospitalized with bacteremia from 1997 to 2002. Individuals treated with statins (n = 176) were identified by record-linkage with the County Prescription Database.

INTERVENTIONS:

None.

MEASUREMENTS AND MAIN RESULTS:

We compared mortality rates 0-30 and 31-180 days after bacteremia in patients with and without preadmission statin use, adjusted for gender, age group, level of comorbidity, alcohol-related conditions, use of immunosuppressive drugs and systemic antibiotics, and focus on infection. The 30-day mortality in statin users vs. nonusers was similar (20.0% vs. 21.6%, adjusted mortality rate ratio 0.93, 95% confidence interval 0.66-1.30). Among survivors after 30 days, however, statin therapy was associated with a substantially decreased mortality up until 180 days after the bacteremia (8.4% vs. 17.5%, adjusted mortality rate ratio 0.44, 95% confidence interval 0.24-0.80). This tendency toward similar short-term and decreased longer term mortality associated with statin use was observed consistently in both community-acquired and nosocomial bacteremia episodes and when analyses were restricted to patients with previous cardiovascular discharge diagnoses or diabetes.

CONCLUSIONS:

This study provides evidence against the hypothesis that statin use has an effect on short-term mortality after bacteremia. Statin use was, however, associated with a substantially decreased mortality between 31 and 180 days after bacteremia.

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PMID:
16484926
[PubMed - indexed for MEDLINE]
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