Cancer Genet Cytogenet. 1991 Jun;53(2):143-60.

Hereditary nonpolyposis colorectal cancer (Lynch syndromes I & II). Genetics, pathology, natural history, and cancer control, Part I.

Lynch HT, Lanspa S, Smyrk T, Boman B, Watson P, Lynch J.

Source

Dept. of Preventive Medicine, Creighton University School of Medicine, Omaha, NE 68178.

Abstract

Hereditary nonpolyposis colorectal cancer (HNPCC) is common, accounting for about 4-6% of the total colorectal cancer burden. It is heterogeneous and appears to be delineated into two clinical subsets, Lynch syndromes I and II. Lynch syndrome I is characterized by an autosomal dominantly inherited proclivity to early onset colonic cancer with proximal predominance and an excess of multiple primary colonic cancer. Lynch syndrome II has all of these features plus extracolonic cancer sites, the most common of which is endometrial carcinoma. The lack of premonitory physical signs or biomarkers of HNPCC makes diagnosis difficult. A careful family history, tempered by an understanding of the clinical and pathologic features of HNPCC, is the key to its assessment. This paper reviews HNPCC's natural history, its integral extracolonic cancer associations, its differential diagnosis, surveillance, and management strategies. Attention is focused upon the need for biomarker research in the interest of improving control of HNPCC.

PMID:: 1648437; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

5 R01 CA 42705-03/CA/NCI NIH HHS/United States

LinkOut - more resources

Full Text Sources

Elsevier Science

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Differential diagnosis of hereditary nonpolyposis colorectal cancer (Lynch syndrome I and Lynch syndrome II). [Dis Colon Rectum. 1988]
Differential diagnosis of hereditary nonpolyposis colorectal cancer (Lynch syndrome I and Lynch syndrome II).
Lynch HT, Watson P, Kriegler M, Lynch JF, Lanspa SJ, Marcus J, Smyrk T, Fitzgibbons RJ Jr, Cristofaro G. Dis Colon Rectum. 1988 May; 31(5):372-7.
Review Hereditary nonpolyposis colorectal cancer--Lynch syndromes I and II. [Gastroenterol Clin North Am. 1...]
Review Hereditary nonpolyposis colorectal cancer--Lynch syndromes I and II.
Lynch HT, Lanspa SJ, Boman BM, Smyrk T, Watson P, Lynch JF, Lynch PM, Cristofaro G, Bufo P, Tauro AV. Gastroenterol Clin North Am. 1988 Dec; 17(4):679-712.
Review The Lynch syndromes. [Curr Opin Oncol. 1993]
Review The Lynch syndromes.
Lynch HT, Lynch JF. Curr Opin Oncol. 1993 Jul; 5(4):687-96.
Review Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review. [Gastroenterology. 1993]
Review Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review.
Lynch HT, Smyrk TC, Watson P, Lanspa SJ, Lynch JF, Lynch PM, Cavalieri RJ, Boland CR. Gastroenterology. 1993 May; 104(5):1535-49.
Hereditary nonpolyposis colon cancer: (Lynch syndrome I and II). A challenge for the clinician. [Nebr Med J. 1989]
Hereditary nonpolyposis colon cancer: (Lynch syndrome I and II). A challenge for the clinician.
Lynch HT, Boman B, Fitzgibbons RJ Jr, Lanspa SJ, Smyrk TC. Nebr Med J. 1989 Jan; 74(1):2-7.

See reviews... See all...

Cited by 14 PubMed Central articles

Review Update on familial pancreatic cancer. [Adv Surg. 2010]
Review Update on familial pancreatic cancer.
Hruban RH, Canto MI, Goggins M, Schulick R, Klein AP. Adv Surg. 2010; 44:293-311.
Hereditary non-polyposis colorectal cancer: clinical and molecular evidence for a new entity of hereditary colorectal cancer. [Gut. 2005]
Hereditary non-polyposis colorectal cancer: clinical and molecular evidence for a new entity of hereditary colorectal cancer.
Mueller-Koch Y, Vogelsang H, Kopp R, Lohse P, Keller G, Aust D, Muders M, Gross M, Daum J, Schiemann U, et al. Gut. 2005 Dec; 54(12):1733-40. Epub 2005 Jun 14.
A common MSH2 mutation in English and North American HNPCC families: origin, phenotypic expression, and sex specific differences in colorectal cancer. [J Med Genet. 1999]
A common MSH2 mutation in English and North American HNPCC families: origin, phenotypic expression, and sex specific differences in colorectal cancer.
Froggatt NJ, Green J, Brassett C, Evans DG, Bishop DT, Kolodner R, Maher ER. J Med Genet. 1999 Feb; 36(2):97-102.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Hereditary nonpolyposis colorectal cancer (Lynch syndromes I & II). Genetics, pa...
Hereditary nonpolyposis colorectal cancer (Lynch syndromes I & II). Genetics, pathology, natural history, and cancer control, Part I.
Cancer Genet Cytogenet. 1991 Jun ;53(2):143-60.

PubMed
Ontogeny of regeneration of beta-cells in the neonatal rat after treatment with ...
Ontogeny of regeneration of beta-cells in the neonatal rat after treatment with streptozotocin.
Endocrinology. 2006 May ;147(5):2346-56. Epub 2006 Feb 16 .

PubMed
Laterality and 3H-imipramine binding: studies in the frontal cortex of normal co...
Laterality and 3H-imipramine binding: studies in the frontal cortex of normal controls and suicide victims.
Biol Psychiatry. 1991 May 15 ;29(10):1016-22.

PubMed
Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac dise...
Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease.
Scand J Gastroenterol. 2006 Feb ;41(2):191-9.

PubMed
Effect of mobile telephony on blood-brain barrier permeability in the fetal mous...
Effect of mobile telephony on blood-brain barrier permeability in the fetal mouse brain.
Pathology. 2006 Feb ;38(1):63-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: