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J Atten Disord. 2006 Feb;9(3):476-85.

A randomized, double-blind, placebo-controlled, laboratory classroom assessment of methylphenidate transdermal system in children with ADHD.

Author information

  • 1University of California, Los Angeles, Semel Institute for Neuroscience and Human Behavior, 90095, USA. jmcgough@mednet.ucla.edu

Abstract

OBJECTIVE:

This study evaluates the efficacy, duration of action, and tolerability of methylphenidate transdermal system (MTS) in children with ADHD.

METHOD:

Participants were dose optimized over 5 weeks utilizing patch doses of 10, 16, 20, and 27 mg applied in the morning and worn for 9 hours. Following optimization, 80 participants were randomized to 1 week of MTS or placebo followed by 1 week of the opposite treatment. Laboratory classroom sessions conducted after each randomized week included blinded ratings of attention, behavior, and academic performance.

RESULTS:

MTS was well tolerated and displayed significant improvement compared with placebo. Improvements were seen at the first postdose time point measured and continued through 12 hours.

CONCLUSIONS:

Treatment with MTS resulted in statistically significant improvements on all efficacy measures. Time course and therapeutic effects of MTS suggest that this novel methylphenidate delivery system is an efficacious once-daily treatment for ADHD.

PMID:
16481664
[PubMed - indexed for MEDLINE]
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