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Intensive Care Med. 2006 Mar;32(3):421-7. Epub 2006 Feb 15.

An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence In Acutely Ill Patients (SOAP) study.

Author information

  • 1Hadassah Hebrew University, Medical Center, Department of Anaesthesiology and Critical Care Medicine, P.O. Box 1200, 91120, Jerusalem, Israel. sprung@cc.huji.ac.il

Abstract

OBJECTIVE:

To define the frequency and prognostic implications of SIRS criteria in critically ill patients hospitalized in European ICUs.

DESIGN AND SETTING:

Cohort, multicentre, observational study of 198 ICUs in 24 European countries.

PATIENTS AND INTERVENTIONS:

All 3,147 new adult admissions to participating ICUs between 1 and 15 May 2002 were included. Data were collected prospectively, with common SIRS criteria.

RESULTS:

During the ICU stay 93% of patients had at least two SIRS criteria [respiratory rate (82%), heart rate (80%)]. The frequency of having three or four SIRS criteria vs. two was higher in infected than non-infected patients (p < 0.01). In non-infected patients having more than two SIRS criteria was associated with a higher risk of subsequent development of severe sepsis (odds ratio 2.6, p < 0.01) and septic shock (odds ratio 3.7, p < 0.01). Organ system failure and mortality increased as the number of SIRS criteria increased.

CONCLUSIONS:

Although common in the ICU, SIRS has prognostic importance in predicting infections, severity of disease, organ failure and outcome.

PMID:
16479382
[PubMed - indexed for MEDLINE]
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