Display Settings:

Format

Send to:

Choose Destination
Trends Cell Biol. 2006 Mar;16(3):125-34. Epub 2006 Feb 14.

Gradients in the self-organization of the mitotic spindle.

Author information

  • 1Cell Biology and Biophysics Program, EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

Abstract

Recent evidence points at a role of protein interaction gradients around chromatin in mitotic spindle morphogenesis in large eukaryotic cells. Here, we explain how gradients can arise over distances of tens of microns around supramolecular structures from mixtures of soluble molecules. We discuss how coupled sets of such reaction diffusion processes generate the spatial information that determines the local dynamics of microtubules required to form a bipolar spindle. We argue that such reaction diffusion processes are involved in the self-organization of supramolecular structures in the cell.

PMID:
16478663
[PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Miscellaneous

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk