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Int J Med Microbiol. 2006 Apr;296(2-3):73-81. Epub 2006 Feb 14.

A network of networks: quorum-sensing gene regulation in Pseudomonas aeruginosa.

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  • 1Department of Microbiology, University of Washington, 1959 NE Pacific Street, HSB I-420, Seattle, WA 98195, USA.


The opportunistic pathogen Pseudomonas aeruginosa possesses two N-acyl-homoserine lactone quorum-sensing systems that regulate large, overlapping sets of genes. Recent global transcriptome and proteome analyses provided a wealth of information about the identity of the regulated genes, N-acyl-homoserine lactone signal specificity, timing of induction, and environmental effects on gene expression. Quorum-sensing gene expression in P. aeruginosa is also embedded in a highly interconnected network of other regulatory systems with a high potential for integrating and responding to multiple environmental signals. Such epigenetic complexity may constitute the basis for the exceptional adaptability of P. aeruginosa to diverse environments.

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