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Cell Res. 2006 Feb;16(2):162-8.

Insight into the biology of macrophage migration inhibitory factor (MIF) revealed by the cloning of its cell surface receptor.

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  • 1Department of Medicine, Yale University School of Medicine, The Anlyan Center, S525, 300 Cedar Street, New Haven CT 06520-8056, USA. Lin.Leng@Yale.edu


The recent cloning of MIF receptor fills an important gap in our understanding of the molecular biology and immunology of MIF. The MIF receptor, like MIF, does not fall into any established family of protein mediators, providing both new challenges and opportunities for the structural and functional analysis of MIF signal transduction.

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