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    Neurobiol Dis. 2006 May;22(2):274-83. Epub 2006 Feb 10.

    Sustained astrocytic clusterin expression improves remodeling after brain ischemia.

    Imhof A, Charnay Y, Vallet PG, Aronow B, Kovari E, French LE, Bouras C, Giannakopoulos P.

    Source

    Department of Psychiatry, HUG, Belle-Idée, 2, ch. du Petit-Bel-Air, 1225 Chêne-Bourg Geneva Switzerland.

    Abstract

    Clusterin is a glycoprotein highly expressed in response to tissue injury. Using clusterin-deficient (Clu-/-) mice, we investigated the role of clusterin after permanent middle cerebral artery occlusion (MCAO). In wild-type (WT) mice, clusterin mRNA displayed a sustained increase in the peri-infarct area from 14 to 30 days post-MCAO. Clusterin transcript was still present up to 90 days post-ischemia in astrocytes surrounding the core infarct. Western blot analysis also revealed an increase of clusterin in the ischemic hemisphere of WT mice, which culminates up to 30 days post-MCAO. Concomitantly, a worse structural restoration and higher number of GFAP-reactive astrocytes in the vicinity of the infarct scar were observed in Clu-/- as compared to WT mice. These findings go beyond previous data supporting a neuroprotective role of clusterin in early ischemic events in that they demonstrate that this glycoprotein plays a central role in the remodeling of ischemic damage.

    PMID:
    16473512
    [PubMed - indexed for MEDLINE]

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