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Int J Radiat Oncol Biol Phys. 2006 Apr 1;64(5):1475-81. Epub 2006 Feb 10.

Protection against radiation-induced oxidative stress in cultured human epithelial cells by treatment with antioxidant agents.

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  • 1Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Abstract

PURPOSE:

To evaluate the protective effects of antioxidant agents against space radiation-induced oxidative stress in cultured human epithelial cells.

METHODS AND MATERIALS:

The effects of selected concentrations of N-acetylcysteine, ascorbic acid, sodium ascorbate, co-enzyme Q10, alpha-lipoic acid, l-selenomethionine, and vitamin E succinate on radiation-induced oxidative stress were evaluated in MCF10 human breast epithelial cells exposed to radiation with X-rays, gamma-rays, protons, or high mass, high atomic number, and high energy particles using a dichlorofluorescein assay.

RESULTS:

The results demonstrated that these antioxidants are effective in protecting against radiation-induced oxidative stress and complete or nearly complete protection was achieved by treating the cells with a combination of these agents before and during the radiation exposure.

CONCLUSION:

The combination of antioxidants evaluated in this study is likely be a promising countermeasure for protection against space radiation-induced adverse biologic effects.

PMID:
16472936
[PubMed - indexed for MEDLINE]
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