My NCBISign In

Display Settings:

Format

Send to:

Choose Destination
    Methods Enzymol. 2006;406:656-65.

    Analysis of a mitotic role of Cdc42.

    Yasuda S, Narumiya S.

    Source

    Department of Pharmacology, Kyoto University, Faculty of Medicine, Japan.

    Abstract

    Rho GTPases including Rho, Rac, and Cdc42 determine the cell shape by regulating the actin and microtubule dynamics. Through these actions on cytoskeleton, Rho GTPases also regulate cell cycle progression. Specifically, Rho, Rac, and Cdc42 regulate G1-S progression, and Rho regulates cytokinesis. However, involvement of these GTPases in nuclear division has not been definitely shown. This seems to be due to the lack of standard procedures examining mitosis-specific functions of these GTPases. Recently, we have found a mitosis-specific role of Cdc42 by enrichment of cells in mitosis by cell cycle synchronization and interfering with functions of Rho GTPases. This chapter describes the procedures we used in these studies.

    PMID:
    16472695
    [PubMed - indexed for MEDLINE]

    MeSH Terms, Substances

    MeSH Terms

    Substances

      Supplemental Content

      Save items

      loading

      Related citations in PubMed

      See reviews... See all...

      Related information

      • Related Citations
        Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
      • Substance (MeSH Keyword)
        PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...
      You are here: NCBI > Literature > PubMed
      Write to the Help Desk