Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Mol Med. 2006 Feb;6(1):99-109.

The control of endoplasmic reticulum-initiated apoptosis by the BCL-2 family of proteins.

Author information

  • 1Department of Pathology, University of California, San Francisco, 94143, USA. scott.oakes@ucsf.edu

Abstract

Irreversible perturbations in the homeostasis of the endoplasmic reticulum (ER) are thought to lead to apoptosis and cell loss in a number of important human diseases, including Alzheimer disease, Parkinson disease, and type 2 diabetes. However, the exact mechanisms that lead from ER stress to cell death remain incompletely understood. Recent work has shown that the BCL-2 family of proteins plays a central role in regulating this form of cell death, both locally at the ER and from a distance at the mitochondrial membrane.

PMID:
16472117
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Bentham Science Publishers Ltd.
    Loading ...
    Write to the Help Desk