Activity-based high-throughput profiling of metalloprotease inhibitors using small molecule microarrays

Chem Commun (Camb). 2006 Feb 21:(7):717-9. doi: 10.1039/b515278j. Epub 2006 Jan 4.

Abstract

We herein describe a high-throughput small molecule microarray (SMM) method that enables quick and cost-effective identification of potent inhibitors of metalloproteases in an activity-dependent manner, thereby offering a rapid means for inhibitor discovery and profiling.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Enzyme Inhibitors / pharmacology*
  • Gene Expression Profiling / economics
  • Gene Expression Profiling / methods*
  • Metalloproteases / antagonists & inhibitors*
  • Microarray Analysis / economics
  • Microarray Analysis / methods*
  • Nanotechnology / economics
  • Nanotechnology / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity

Substances

  • Enzyme Inhibitors
  • Metalloproteases