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Curr Opin Immunol. 2006 Apr;18(2):164-74. Epub 2006 Feb 7.

AID in somatic hypermutation and class switch recombination.

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  • 1Department of Molecular Genetics and Cell Biology, University of Chicago, 920 E. 58(th) Street, Chicago, IL 60615, USA.


Somatic hypermutation and class-switch-recombination are initiated by the deamination of deoxycytosine in DNA by activation-induced-deaminase, AID. Recently, there has been much research into how AID targets double-stranded DNA in sub-regions of Ig genes, the involvement of co-factors and posttranslational modifications in this process, the co-option of DNA 'repair' mechanisms and AID evolution.

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