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Eur Urol. 2006 May;49(5):790-7. Epub 2006 Jan 24.

Management of BCG failures in superficial bladder cancer: a review.

Author information

  • Department of Urology, University Medical Centre St. Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands. F.Witjes@uro.umcn.nl

Abstract

OBJECTIVE:

Review management of bacillus Calmette-Guérin (BCG) failures in superficial bladder cancer.

METHOD:

Search of published literature and meeting abstracts.

RESULTS:

Patients in whom BCG fails are not a uniform group. Failure cannot be predicted but high-risk patients can be identified. In case of failure and progression the outcome is bad. Conservative but investigative alternatives are BCG/interferon-alpha, intravesical hyperthermia/chemotherapy, or photodynamic therapy. Standard treatment in failing patients remains cystoprostatectomy.

CONCLUSION:

BCG failures need careful and individualized therapy in experienced hands.

Comment in

PMID:
16464532
[PubMed - indexed for MEDLINE]
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