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Nano Lett. 2006 Feb;6(2):306-12.

Proteolytic surface functionalization enhances in vitro magnetic nanoparticle mobility through extracellular matrix.

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  • 1Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235, USA.


Steric barriers such as collagen I sharply limit interstitial delivery of macromolecular and nanoparticle (NP) based therapeutic agents. Collagenase-linked superparamagnetic NPs overcame these barriers and moved through in vitro extracellular matrix (ECM) at 90 microm h(-1), a rate similar to invasive cells, under the influence of a magnetic field. NP migration in ECM diminished linearly over 5 days. The collagenase-NP construct overcame two of the most significant barriers to nano- and microscale therapeutics deployment: proteolytic enzyme stability was maintained during a clinically useful time frame by immobilization on the NP surface and degradation of interstitial barriers to tissue biodistribution was enabled by the conjugated microbial protease.

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