Nat Immunol. 2006 Mar;7(3):311-7. Epub 2006 Feb 5.

Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2.

Source

Infectious Disease Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, Immunology Program, Sloan-Kettering Institute, New York, New York 10021, USA. serbinan@mskcc.org

Abstract

Monocytes recruited to tissues mediate defense against microbes or contribute to inflammatory diseases. Regulation of the number of circulating monocytes thus has implications for disease pathogenesis. However, the mechanisms controlling monocyte emigration from the bone marrow niche where they are generated remain undefined. We demonstrate here that the chemokine receptor CCR2 was required for emigration of Ly6C(hi) monocytes from bone marrow. Ccr2(-/-) mice had fewer circulating Ly6C(hi) monocytes and, after infection with Listeria monocytogenes, accumulated activated monocytes in bone marrow. In blood, Ccr2(-/-) monocytes could traffic to sites of infection, demonstrating that CCR2 is not required for migration from the circulation into tissues. Thus, CCR2-mediated signals in bone marrow determine the frequency of Ly6C(hi) monocytes in the circulation.

Comment in

Nat Immunol. 2006 Mar;7(3):230-2.

PMID:: 16462739; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression. [J Immunol. 2010]
Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression.
Shi C, Velázquez P, Hohl TM, Leiner I, Dustin ML, Pamer EG. J Immunol. 2010 Jun 1; 184(11):6266-74. Epub 2010 Apr 30.
Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection. [J Immunol. 2008]
Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection.
Jia T, Serbina NV, Brandl K, Zhong MX, Leiner IM, Charo IF, Pamer EG. J Immunol. 2008 May 15; 180(10):6846-53.
CCR2 mediates homeostatic and inflammatory release of Gr1(high) monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection. [J Immunol. 2008]
CCR2 mediates homeostatic and inflammatory release of Gr1(high) monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection.
Engel DR, Maurer J, Tittel AP, Weisheit C, Cavlar T, Schumak B, Limmer A, van Rooijen N, Trautwein C, Tacke F, et al. J Immunol. 2008 Oct 15; 181(8):5579-86.
Review Monocyte-mediated immune defense against murine Listeria monocytogenes infection. [Adv Immunol. 2012]
Review Monocyte-mediated immune defense against murine Listeria monocytogenes infection.
Serbina NV, Shi C, Pamer EG. Adv Immunol. 2012; 113:119-34.
Review Monocyte-mediated defense against microbial pathogens. [Annu Rev Immunol. 2008]
Review Monocyte-mediated defense against microbial pathogens.
Serbina NV, Jia T, Hohl TM, Pamer EG. Annu Rev Immunol. 2008; 26:421-52.

See reviews... See all...

Cited by over 100 PubMed Central articles

Lack of PPARγ in Myeloid Cells Confers Resistance to Listeria monocytogenes Infection. [PLoS One. 2012]
Lack of PPARγ in Myeloid Cells Confers Resistance to Listeria monocytogenes Infection.
Abdullah Z, Geiger S, Nino-Castro A, Böttcher JP, Muraliv E, Gaidt M, Schildberg FA, Riethausen K, Flossdorf J, Krebs W, et al. PLoS One. 2012; 7(5):e37349. Epub 2012 May 21.
Characteristics of "Tip-DCs and MDSCs" and Their Potential Role in Leishmaniasis. [Front Microbiol. 2012]
Characteristics of "Tip-DCs and MDSCs" and Their Potential Role in Leishmaniasis.
Schmid M, Wege AK, Ritter U. Front Microbiol. 2012; 3:74. Epub 2012 Mar 12.
Depletion of dendritic cells enhances innate anti-bacterial host defense through modulation of phagocyte homeostasis. [PLoS Pathog. 2012]
Depletion of dendritic cells enhances innate anti-bacterial host defense through modulation of phagocyte homeostasis.
Autenrieth SE, Warnke P, Wabnitz GH, Lucero Estrada C, Pasquevich KA, Drechsler D, Günter M, Hochweller K, Novakovic A, Beer-Hammer S, et al. PLoS Pathog. 2012 Feb; 8(2):e1002552. Epub 2012 Feb 23.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Monocyte emigration from bone marrow during bacterial infection requires signals...
Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2.
Nat Immunol. 2006 Mar ;7(3):311-7. Epub 2006 Feb 5 .

PubMed
Bone morphogenetic protein gene therapy using a fibrin scaffold for a rabbit spi...
Bone morphogenetic protein gene therapy using a fibrin scaffold for a rabbit spinal-fusion experiment.
Neurosurgery. 2006 Feb ;58(2):373-80; discussion 373-80.

PubMed
Hyperglycemia in the critically ill patient.
Hyperglycemia in the critically ill patient.
AACN Clin Issues. 2006 Jan-Mar ;17(1):50-5.

PubMed
Pharmacokinetics, safety, and pharmacologic effects of fosinopril sodium, an ang...
Pharmacokinetics, safety, and pharmacologic effects of fosinopril sodium, an angiotensin-converting enzyme inhibitor in healthy subjects.
J Clin Pharmacol. 1991 Jan ;31(1):58-64.

PubMed
Suprascapular nerve reconstruction in 118 cases of adult posttraumatic brachial ...
Suprascapular nerve reconstruction in 118 cases of adult posttraumatic brachial plexus.
Plast Reconstr Surg. 2006 Feb ;117(2):613-29.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2.

Source

Abstract

Comment in

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Research Materials

Miscellaneous

Supplemental Content

Save items

Related citations in PubMed

Cited by over 100 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information