An angiotensin-I converting enzyme inhibitor from buckwheat (Fagopyrum esculentum Moench) flour

Phytochemistry. 2006 Mar;67(6):618-21. doi: 10.1016/j.phytochem.2005.12.022. Epub 2006 Feb 3.

Abstract

A compound that inhibited angiotensin-I converting enzyme (ACE) activity was isolated from buckwheat powder. This compound is thought to be the hydroxy derivative of nicotianamine and its chemical structure is 2''-hydroxynicotianamine. This compound showed a very high inhibitory activity toward ACE, and the IC(50) was 0.08 microM. Only this hydroxy analog was found in buckwheat powder, at about 30 mg/100g, and no nicotianamine was detected. However, nicotianamine was detected in the buckwheat plant body. 2''-hydroxynicotianamine was also found in other polygonaceous plants.

MeSH terms

  • Angiotensin-Converting Enzyme Inhibitors / chemistry
  • Angiotensin-Converting Enzyme Inhibitors / isolation & purification*
  • Angiotensin-Converting Enzyme Inhibitors / pharmacology*
  • Azetidinecarboxylic Acid / analogs & derivatives
  • Azetidinecarboxylic Acid / chemistry
  • Azetidinecarboxylic Acid / pharmacology
  • Fagopyrum / chemistry*
  • Flour*
  • Inhibitory Concentration 50
  • Molecular Structure
  • Peptidyl-Dipeptidase A / metabolism

Substances

  • Angiotensin-Converting Enzyme Inhibitors
  • nicotianamine
  • Azetidinecarboxylic Acid
  • Peptidyl-Dipeptidase A