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Anal Bioanal Chem. 2006 Jan;384(1):85-99.

From fundamentals to applications: recent developments in atmospheric pressure photoionization mass spectrometry.

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  • 1Chemical Analysis Group and MESA+ Institute for Nanotechnology, University of Twente, Enschede, The Netherlands.


Only five years after the first publication on atmospheric pressure photoionization (APPI), this technique has evolved rapidly as a very useful complement to established ionization techniques for liquid chromatography/mass spectrometry (LC/MS). This is reflected in a rapidly increasing number of publications in this field. On the one hand, thorough studies into the photoionization mechanism have provided deep insights into the roles and influences of the solvent, the dopant and other additives. On the other hand, a large number of new and attractive applications have recently been introduced. New instrumental developments have resulted in combined APPI/ESI (PAESI) and APPI/APCI sources and a microfabricated APPI source. In this review, the most important developments within the field are summarized, focusing in particular on the applications of the technique.

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