Your browser version may not work well with NCBI's Web applications. More information here...
1: J Biomed Sci. 2006 Mar;13(2):205-13. Epub 2006 Feb 3.Links

Mitosin/CENP-F in mitosis, transcriptional control, and differentiation.

Ma L, Zhao X, Zhu X.

Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.

Mitosin/CENP-F is a large nuclear/kinetochore protein containing multiple leucine zipper motifs potentially for protein interactions. Its expression levels and subcellular localization patterns are regulated in a cell cycle-dependent manner. Recently, accumulating lines of evidence have suggested it a multifunctional protein involved in mitotic control, microtubule dynamics, transcriptional regulation, and muscle cell differentiation. Consistently, it is shown to interact directly with a variety of proteins including CENP-E, NudE/Nudel, ATF4, and Rb. Here we review the current progress and discuss possible mechanisms through which mitosin may function.

PMID: 16456711 [PubMed - indexed for MEDLINE]