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Bioorg Med Chem Lett. 2006 Apr 15;16(8):2243-6. Epub 2006 Feb 7.

Factor VIIa inhibitors: improved pharmacokinetic parameters.

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  • 1Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA.


Efforts to improve the potency and pharmacokinetic properties of small molecule factor VIIa inhibitors are described. Small structural modifications to existing leads allow the modulation of half-life and clearance, potentially making these compounds suitable candidates for drug development.

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