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J Perinatol. 2006 Mar;26(3):189-96.

Early variable-flow nasal continuous positive airway pressure in infants < or =1000 grams at birth.

Author information

  • 1Department of Pediatrics, University of California San Francisco, CA 94143-0748, USA.

Abstract

OBJECTIVE:

To compare the incidence of chronic lung disease (CLD) in extremely low birth weight (ELBW, < or =1000 g) infants before and after the introduction of early, preferential application of nasal continuous airway pressure (NCPAP) utilizing a variable flow delivery system.

STUDY DESIGN:

A retrospective cohort study of ELBW infants 2 years prior to (Pre-early NCPAP, n=96) and 2 years following (Early NCPAP, n=75) the initiation of an early NCPAP policy.

RESULTS:

There were no significant changes (Pre-early NCPAP vs Early NCPAP) in the incidences of CLD (35 vs 33%, P=0.81) or CLD or death (50 vs 43%, P=0.34). Infants in the Early NCPAP group weaned off mechanical ventilation and supplemental oxygen more rapidly than infants in the Pre-early NCPAP group (hazard ratio (HR) 1.80, P=0.002 and HR 1.69, P=0.01).

CONCLUSION:

A policy of early NCPAP has not decreased the incidence of CLD despite a decrease in time to successful tracheal extubation.

PMID:
16453007
[PubMed - indexed for MEDLINE]
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