Br J Psychiatry. 2006 Feb;188:105-6.

Two-week delay in onset of action of antidepressants: new evidence.

Abstract

Many sources purport that antidepressants have a delayed onset of action, measured in weeks rather than days. Recent data using weekly or daily mood ratings demonstrate that maximum improvement occurs during the first 2 weeks, with some improvement within the first 3 days. Methodological issues may underlie the delayed-onset hypothesis.

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