Abstract

OBJECTIVE:

To study the effect of Shenqi Fuzheng injection on the humoral immunity (IgG IgM IgA), cellular immunity (T-lymphocyte subsets), Superoxide dismutase (SOD). Lpo and Plasma viscosity in the patients with congestive heart failure (CHF).

METHODS:

Sixty patients with CHF, whose heart function belonged to NYHA grade II-IV were randomly divide into two groups. The treaded group were treated with SFI 100 ml, and the control group were treated by nitroglycerine in jection 10 mg, the drug were administered respectively by adding in 5% glucose solution 500 ml for intravenous dripping, once a day, 20 days as one therapeutic course. Venous blood from cubital vein was collected before and after treatment to detect the IgG, IgM, IgA, T-lymphocyte subsets, SOD, LPO and Plasma viscosity.

RESULTS:

The clinical heart function markedly improved rate and total effective rate in the treated group was singificantly better than those in the control group respectively (P < 0.05). the left ventricular ejecting frection (LVEF) and end syctolic volume (ESV) were improved in both group (P < 0.05, P < 0.01), and the improvement in the treated group was superior to that in the control group (P < 0.05). In the treated group after treatment, the CD4, SOD level and CD4/DC8 ratio increased (P < 0.05), level of LPO, IgG and IgM lowered (P < 0.05) significantly, while those in the control group were not changed singificantly (P > 0.05). Plasma viscosity of treatment group also got better improved than before (P < 0.05), and there was a significantly difference between the two groups after treatment (P < 0.05).

CONCLUSION:

SFI Can improve the immune funtion of CHF patients, and can be taken as an importmant auxiliary treatment for CHF.