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Eur Biophys J. 2006 May;35(5):446-50. Epub 2006 Jan 31.

Targeting cancer cells: magnetic nanoparticles as drug carriers.

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  • 1Klinik und Poliklinik für Hals- Nasen- Ohren- kranke, Universität Erlangen - Nürnberg, Erlangen, Germany. C.Alexiou@web.de

Abstract

Magnetic drug targeting employing nanoparticles as carriers is a promising cancer treatment avoiding side effects of conventional chemotherapy. We used iron oxide nanoparticles covered by starch derivatives with phosphate groups which bound mitoxantrone as chemotherapeutikum. In this letter we show that a strong magnetic field gradient at the tumour location accumulates the nanoparticles. Electron microscope investigations show that the ferrofluids can be enriched in tumour tissue and tumour cells.

[PubMed - indexed for MEDLINE]
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