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Georgian Med News. 2005 Dec;(129):138-41.

[Oxidative stress as common pathological phenomenon and possibilities of its correction].

[Article in Russian]

Abstract

It was shown that disorders of oxidative metabolism play an important role in the pathological processes which develops at subcellular level -- disorder of electron transport at ubichinon-oxidoreductase locus of respiratory chain in mitochondria. The latter could be discussed as common pathological phenomenon determining oxidative stress. It is found that altered synthesis and metabolism of nitric oxide plays an important role in the pathogenesis of oxidative stress. It has been detected the ways and mechanisms of disorders of NO synthesis and conversion. The negative role of widespread and irrational use of antioxidant therapy and "universal" antioxidant treatment was characterized.

PMID:
16444055
[PubMed - indexed for MEDLINE]
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