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    Physiology (Bethesda). 2006 Feb;21:48-60.

    AMPK: a key sensor of fuel and energy status in skeletal muscle.

    Source

    Division of Molecular Physiology, University of Dundee, Dundee, Scotland. d.g.hardie@dundee.ac.uk

    Abstract

    Contraction induces marked metabolic changes in muscle, and the AMP-activated protein kinase (AMPK) is a good candidate to explain these effects. Recent work using a muscle-specific knockout of the upstream kinase, LKB1, has confirmed that the LKB1-->AMPK cascade is the signaling pathway responsible for many of these effects.

    PMID:
    16443822
    [PubMed - indexed for MEDLINE]
    Free full text

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