Format

Send to:

Choose Destination
See comment in PubMed Commons below
Physiology (Bethesda). 2006 Feb;21:29-37.

Intrauterine programming of physiological systems: causes and consequences.

Author information

  • 1Department of Physiology, University of Cambridge, Cambridge, UK. alf1000@cam.ac.uk

Abstract

The intrauterine conditions in which the mammalian fetus develops have an important role in regulating the function of its physiological systems later in life. Changes in the intrauterine availability of nutrients, oxygen, and hormones program tissue development and lead to abnormalities in adult cardiovascular and metabolic function in several species. The timing, duration, severity, and type of insult during development determines the specific physiological outcome. Intrauterine programming of physiological systems occurs at the gene, cell, tissue, organ, and system levels and causes permanent structural and functional changes, which can lead to overt disease, particularly with increasing age.

PMID:
16443820
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk