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EMBO Rep. 2006 Apr;7(4):444-9. Epub 2006 Jan 27.

Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia.

Author information

  • 1Hubrecht Laboratorium, NIOB/KNAW, Center for Biomedical Genetics, CT Utrecht, The Netherlands.

Abstract

Truncation of the tumour suppressor adenomatous polyposis coli (APC) constitutively activates the Wnt/beta-catenin signalling pathway. This event constitutes the primary transforming event in sporadic colorectal cancer in humans. Moreover, humans or mice carrying germline truncating mutations in APC develop large numbers of intestinal adenomas. Here, we report that zebrafish that are heterozygous for a truncating APC mutation spontaneously develop intestinal, hepatic and pancreatic neoplasias that are highly proliferative, accumulate beta-catenin and express Wnt target genes. Treatment with the chemical carcinogen 7,12-dimethylbenz[a]anthracene accelerates the induction of these lesions. These observations establish apc-mutant zebrafish as a bona fide model for the study of digestive tract cancer.

PMID:
16439994
[PubMed - indexed for MEDLINE]
PMCID:
PMC1456916
Free PMC Article

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