The analgesic activity of paracetamol is prevented...[Eur J Pharmacol. 2006]

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1: Eur J Pharmacol. 2006 Feb 15;531(1-3):280-1. Epub 2006 Jan 24. Links

The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors.

Ottani A, Leone S, Sandrini M, Ferrari A, Bertolini A.

Department of Biomedical Sciences, Section of Pharmacology, University of Modena and Reggio Emilia, Via G. Campi 287, 41100 Modena, Italy.

The mechanism of the analgesic activity of paracetamol (acetaminophen), one of the most widely used drugs for the treatment of pain, is still not clear. Here we show that in rats, using the hot plate test, the analgesic effect of paracetamol is prevented by two antagonists at cannabinoid CB1 receptors (AM281 and SR141716A) at doses that prevent the analgesic activity of the cannabinoid CB1 agonist HU210. Our present results suggest that paracetamol-induced antinociception involves the cannabinoid system.

PMID: 16438952 [PubMed - indexed for MEDLINE]

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Acetaminophen (Acephen® , Anacin® Aspirin Free Maximum Strength Tablets® , Capital® and Codeine, ...)
Acetaminophen is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever. Acetamino...
Dronabinol (Marinol® )
Dronabinol is used to treat nausea and vomiting caused by chemotherapy in people who have already taken other medications to treat this type of nausea and vomiting without good results. Dronabinol is also used to treat l...
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