Bisphosphonate-related osteonecrosis of the jaws

Singapore Dent J. 2005 Dec;27(1):36-40.

Abstract

The purpose of this paper is to highlight an emerging phenomenon of osteonecrosis of the jaws that occurs in some patients who are on long-term bisphosphonate therapy. The condition can appear spontaneously or as a result of trauma, and is difficult to treat. Dental surgeons must be aware of patients who are at risk and institute appropriate preventive care. It is also important to recognize the condition when it does appear and refer appropriately. We present the first local case series of the condition showing varied clinical presentations and treatments.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Agents / adverse effects*
  • Bone Density Conservation Agents / adverse effects*
  • Diphosphonates / adverse effects*
  • Female
  • Humans
  • Male
  • Mandibular Diseases / chemically induced
  • Mandibular Diseases / therapy
  • Maxillary Diseases / chemically induced
  • Maxillary Diseases / therapy
  • Middle Aged
  • Osteonecrosis / chemically induced*
  • Osteonecrosis / therapy
  • Tooth Extraction / adverse effects

Substances

  • Antineoplastic Agents
  • Bone Density Conservation Agents
  • Diphosphonates