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FASEB J. 2006 Apr;20(6):720-2. Epub 2006 Jan 25.

Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process.

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  • 1Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA.

Abstract

Fibroblast growth factor 23 null mice (Fgf-23-/-) have a short lifespan and show numerous biochemical and morphological features consistent with premature aging-like phenotypes, including kyphosis, severe muscle wasting, hypogonadism, osteopenia, emphysema, uncoordinated movement, T cell dysregulation, and atrophy of the intestinal villi, skin, thymus, and spleen. Furthermore, increased vitamin D activities in homozygous mutants are associated with severe atherosclerosis and widespread soft tissue calcifications; ablation of vitamin D activity from Fgf-23-/- mice, by genetically deleting the 1alpha(OH)ase gene, eliminates atherosclerosis and ectopic calcifications and significantly rescues premature aging-like features of Fgf-23-/- mice, resulting in prolonged survival of Fgf-23-/-/1alpha(OH)ase-/- double mutants. Our results indicate a novel role of Fgf-23 in developing premature aging-like features through regulating vitamin D homeostasis. Finally, our data support a new model of interactions among Fgf-23, vitamin D, and klotho, a gene described as being associated with premature aging process.

PMID:
16436465
[PubMed - indexed for MEDLINE]
PMCID:
PMC2899884
Free PMC Article
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