Cancer Genet Cytogenet. 2006 Jan 15;164(2):155-8.

Cutaneous aneurysmal fibrous histiocytoma with a t(12;19)(p12;q13) as the sole cytogenetic anomaly.

Source

Department of Clinical Oncology, Katholieke Universiteit Leuven, O & N Gasthuisberg, Leuven, Belgium.

Abstract

We report a case of a 39-year-old woman with a recurrent aneurysmal fibrous histiocytoma of the right lower leg. Cytogenetic analysis of the tumor specimen disclosed a 46,XX,t(12;19)(p12;q13) karyotype. Multicolor fluorescence in situ hybridization (M-FISH), followed by conventional FISH analysis, confirmed the reciprocal translocation as the sole cytogenetic anomaly, and allowed for the positioning of chromosomes 12 and 19 breakpoints proximal to the BCL3 gene and between ETV6 and PIK3C2G gene loci, respectively. Our case highlights the importance of distinguishing this recurrent but benign lesion from similarly appearing malignant skin tumors. Cytogenetic analysis may contribute to the diagnosis of this uncommon but distinctive clinicopathological entity.

PMID:: 16434321; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Medical

Skin Cancer - MedlinePlus Health Information

Supplemental Content

Related citations

Cellular fibrous histiocytoma of the skin: evidence of a clonal process with different karyotype from dermatofibrosarcoma. [Genes Chromosomes Cancer. 1997]
Cellular fibrous histiocytoma of the skin: evidence of a clonal process with different karyotype from dermatofibrosarcoma.
Vanni R, Marras S, Faa G, Licheri S, Daniele GM, Fletcher CD. Genes Chromosomes Cancer. 1997 Apr; 18(4):314-7.
[Clear cell dermatofibroma: a case report with cytogenetic study]. [Ann Pathol. 2004]
[Clear cell dermatofibroma: a case report with cytogenetic study].
Riopel C, Musette P, Bodenant C, Belanyi P, Joly P, Courville P. Ann Pathol. 2004 Oct; 24(5):440-5; quiz 393.
Disruption of the ETV6 gene as a consequence of a rare translocation (12;12)(p13;q13) in treatment-induced acute myeloid leukemia after breast cancer. [Cancer Genet Cytogenet. 2008]
Disruption of the ETV6 gene as a consequence of a rare translocation (12;12)(p13;q13) in treatment-induced acute myeloid leukemia after breast cancer.
Manola KN, Georgakakos VN, Margaritis D, Stavropoulou C, Panos C, Kotsianidis I, Pantelias GE, Sambani C. Cancer Genet Cytogenet. 2008 Jan 1; 180(1):37-42.
Review Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Dermatofibrosarcoma protuberans and giant cell fibroblastoma. [Cancer Genet Cytogenet. 2003]
Review Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Dermatofibrosarcoma protuberans and giant cell fibroblastoma.
Sandberg AA, Bridge JA. Cancer Genet Cytogenet. 2003 Jan 1; 140(1):1-12.
Review Endometrial stromal sarcoma with a sole t(X;17) chromosome change: report of a case and review of the literature. [Gynecol Oncol. 2003]
Review Endometrial stromal sarcoma with a sole t(X;17) chromosome change: report of a case and review of the literature.
Amant F, Moerman P, Cadron I, Hagemeijer A, Vergote I, Debiec-Rychter M. Gynecol Oncol. 2003 Mar; 88(3):459-62.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cancer Chromosomes
Cancer chromosome records that cite the current articles.

Recent activity

Clear Turn Off Turn On

Cutaneous aneurysmal fibrous histiocytoma with a t(12;19)(p12;q13) as the sole c...
Cutaneous aneurysmal fibrous histiocytoma with a t(12;19)(p12;q13) as the sole cytogenetic anomaly.
Cancer Genet Cytogenet. 2006 Jan 15 ;164(2):155-8.

PubMed
Hemosiderotic dermatofibroma: report of one case.
Hemosiderotic dermatofibroma: report of one case.
Dermatology. 2007 ;214(1):82-4.

PubMed
Dermoscopic findings of haemosiderotic and aneurysmal dermatofibroma: report of ...
Dermoscopic findings of haemosiderotic and aneurysmal dermatofibroma: report of six patients.
Br J Dermatol. 2006 Feb ;154(2):244-50.

PubMed
Report of an angiosarcoma mimic: cutaneous aneurysmal fibrous histiocytoma.
Report of an angiosarcoma mimic: cutaneous aneurysmal fibrous histiocytoma.
APMIS. 2006 Oct ;114(10):744-8.

PubMed
Aneurysmal benign fibrous histiocytoma: clinicopathological analysis of 40 cases...
Aneurysmal benign fibrous histiocytoma: clinicopathological analysis of 40 cases of a tumour frequently misdiagnosed as a vascular neoplasm.
Histopathology. 1995 Apr ;26(4):323-31.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Cutaneous aneurysmal fibrous histiocytoma with a t(12;19)(p12;q13) as the sole cytogenetic anomaly.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Related citations

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information