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    Infect Immun. 2006 Feb;74(2):1376-80.

    Pathogen-accelerated atherosclerosis occurs early after exposure and can be prevented via immunization.

    Miyamoto T, Yumoto H, Takahashi Y, Davey M, Gibson FC 3rd, Genco CA.

    Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, Evans Biomedical Research Center, Room 637, 650 Albany St., Boston, MA 02118, USA.

    Here we report on early inflammatory events associated with Porphyromonas gingivalis-accelerated atherosclerosis in apolipoprotein E knockout (ApoE-/-) mice. Animals challenged with P. gingivalis presented with increased macrophage infiltration, innate immune marker expression, and atheroma without elevated systemic inflammatory mediators. This early local inflammatory response was prevented in mice immunized with P. gingivalis. We conclude that localized up-regulation of innate immune markers early after infection, rather than systemic inflammation, contributes to pathogen-accelerated atherosclerosis.

    PMID: 16428788 [PubMed - indexed for MEDLINE]

    PMCID: 1360301

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