Anti-inflammatory activity of alkanoids and triterpenoids from Trichodesma amplexicaule Roth

B Singh; P M Sahu; R K Lohiya; M K Sharma; H L Singh; S Singh

doi:10.1016/j.phymed.2004.06.018

Anti-inflammatory activity of alkanoids and triterpenoids from Trichodesma amplexicaule Roth

Phytomedicine. 2006 Feb;13(3):152-6. doi: 10.1016/j.phymed.2004.06.018. Epub 2005 Jun 29.

Authors

B Singh¹, P M Sahu, R K Lohiya, M K Sharma, H L Singh, S Singh

Affiliation

¹ Department of Botany, University of Rajasthan, Jaipur, India.

PMID: 16428021
DOI: 10.1016/j.phymed.2004.06.018

Abstract

The phytochemical investigation of Trichodesma amplexicaule guided by bioassay, to isolation of triterpenoids and aliphatic phytoconstituents. To evaluate the anti-inflammatory activities of isolated phytoconstituents, models with carrageenan-induced acute arthritis and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats were conducted. The investigated results showed that alkanoic acid significantly inhibited the carrageenan-induced acute arthritis. Moreover, alkane also supressed the development of chronic arthritis induced by CFA. It has been reported that alkane was the major phytoconstituent (1.03 +/- 0.00135%) in in vivo studies.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkanes / chemistry
Alkanes / pharmacology*
Alkanes / therapeutic use
Animals
Anti-Inflammatory Agents / pharmacology*
Anti-Inflammatory Agents / therapeutic use
Arthritis, Experimental / drug therapy*
Biological Assay / methods
Boraginaceae / chemistry*
Disease Models, Animal
Edema / chemically induced
Edema / drug therapy
Freund's Adjuvant / toxicity
Indomethacin / pharmacology
Indomethacin / therapeutic use
Male
Rats
Rats, Wistar
Triterpenes / chemistry
Triterpenes / pharmacology*
Triterpenes / therapeutic use

Substances

Alkanes
Anti-Inflammatory Agents
Triterpenes
Freund's Adjuvant
Indomethacin